Reconstruction of the microalga Nannochloropsis salina genome-scale metabolic model with applications to lipid production.

ABSTRACT:

Background

Nannochloropsis salina (= Eustigmatophyceae) is a marine microalga which has become a biotechnological target because of its high capacity to produce polyunsaturated fatty acids and triacylglycerols. It has been used as a source of biofuel, pigments and food supplements, like Omega 3. Only some Nannochloropsis species have been sequenced, but none of them benefit from a genome-scale metabolic model (GSMM), able to predict its metabolic capabilities.

Results

We present iNS934, the first GSMM for N. salina, including 2345 reactions, 934 genes and an exhaustive description of lipid and nitrogen metabolism. iNS934 has a 90% of accuracy when making simple growth/no-growth predictions and has a 15% error rate in predicting growth rates in different experimental conditio

SUBMITTER: Loira N 

PROVIDER: S-EPMC5496344 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature