Familial aggregation of focal seizure semiology in the Epilepsy Phenome/Genome Project.

ABSTRACT:

Objective

To improve phenotype definition in genetic studies of epilepsy, we assessed the familial aggregation of focal seizure types and of specific seizure symptoms within the focal epilepsies in families from the Epilepsy Phenome/Genome Project.

Methods

We studied 302 individuals with nonacquired focal epilepsy from 149 families. Familial aggregation was assessed by logistic regression analysis of relatives' traits (dependent variable) by probands' traits (independent variable), estimating the odds ratio for each symptom in a relative given presence vs absence of the symptom in the proband.

Results

In families containing multiple individuals with nonacquired focal epilepsy, we found significant evidence for familial aggregation of ictal motor, autonomic, psychic, a

SUBMITTER: Tobochnik S 

PROVIDER: S-EPMC5496514 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature