Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes.

ABSTRACT: The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py₂TiCl₂NPh]₂ is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either α,β-unsaturated imines or α-(iminomethyl)cyclopropanes via a Ti^II/Ti^IV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either β-H elimination or α,γ-coupling, wherein the selectivity is under substrate control.

SUBMITTER: Davis-Gilbert ZW 

PROVIDER: S-EPMC5496654 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature