Ontology highlight
ABSTRACT:
SUBMITTER: Mobley RJ
PROVIDER: S-EPMC5496714 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell reports 20170301 10
The first epithelial-to-mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TS<sup>KI4</sup> cells) induces an intermediate state of EMT, where cells retain stemness, lose epithelial markers, and gain mesenchymal characteristics. Investigation of relationships among MAP3K4 activity, stemness, and EMT in TS cells may reveal key regulators of EMT. Here, we show that MAP3K4 activity controls EMT thro ...[more]