Systems characterization of differential plasma metabolome perturbations following thrombotic and non-thrombotic myocardial infarction.

ABSTRACT: Myocardial infarction (MI) is an acute event characterized by myocardial necrosis. Thrombotic MI is caused by spontaneous atherosclerotic plaque disruption that results in a coronary thrombus; non-thrombotic MI occurs secondary to oxygen supply-demand mismatch. We sought to characterize the differential metabolic perturbations associated with these subtypes utilizing a systems approach. Subjects presenting with thrombotic MI, non-thrombotic MI and stable coronary artery disease (CAD) were included. Whole blood was collected at two acute time-points and at a time-point representing the quiescent stable disease state. Plasma metabolites were analyzed by untargeted UPLC-MS/MS and GC-MS. A weighted network was constructed, and modules were determined from the resulting topology. To determine p

SUBMITTER: Trainor PJ 

PROVIDER: S-EPMC5496773 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature