Dataset Information

Tackling inpatient penicillin allergies: Assessing tools for antimicrobial stewardship.

ABSTRACT:

Background

Reported penicillin allergy rarely reflects penicillin intolerance. Failure to address inpatient penicillin allergies results in more broad-spectrum antibiotic use, treatment failures, and adverse drug events.

Objective

We aimed to determine the optimal approach to penicillin allergies among medical inpatients.

Methods

We evaluated internal medicine inpatients reporting penicillin allergy in 3 periods: (1) standard of care (SOC), (2) penicillin skin testing (ST), and (3) computerized guideline application with decision support (APP). The primary outcome was use of a penicillin or cephalosporin, comparing interventions to SOC using multivariable logistic regression.