Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

ABSTRACT:

Introduction

Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.

Methods

We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.

Results

Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 × 10^-8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3,

SUBMITTER: Jun GR 

PROVIDER: S-EPMC5496797 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature