Changes in obstructive sleep apnea severity, biomarkers, and quality of life after multilevel surgery.

ABSTRACT:

Objectives/hypothesis

To evaluate the impact of multilevel obstructive sleep apnea surgical treatment on sleep-disordered breathing severity, health-related measures, and quality of life, and to examine the association between changes in sleep-disordered breathing severity and these other outcomes.

Study design

Prospective cohort study.

Methods

Subjects with obstructive sleep apnea unable to tolerate positive airway pressure therapy and with evidence of multilevel (palate and hypopharynx) obstruction underwent uvulopalatopharyngoplasty, tonsillectomy, and genioglossus advancement, with or without hyoid suspension. All subjects had preoperative and postoperative study assessments, including blood draw for C-reactive protein, interleukin-6, homocysteine, homeostasis mod

SUBMITTER: Kezirian EJ 

PROVIDER: S-EPMC5496819 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature