Lesions to polar/orbital prefrontal cortex selectively impair reasoning about emotional material.

ABSTRACT: While it is widely accepted that lesions to orbital prefrontal cortex lead to emotion related disruptions and poor decision-making, there is very little patient data on this issue involving actual logical reasoning tasks. We tested patients with circumscribed, focal lesions largely confined to polar/orbital prefrontal cortex (BA 10 & 11) (N=17) on logical reasoning tasks involving neutral and emotional content, and compared their performance to that of an age and education-matched normal control group (N=22) and a posterior lesion control group (N=24). Our results revealed a significant group by content interaction driven by a selective impairment in the polar/orbital prefrontal cortex group compared to healthy normal controls and to the parietal patient group, in the emotional content rea

SUBMITTER: Goel V 

PROVIDER: S-EPMC5496820 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature