Boronic Acid-Modified Magnetic Fe₃O₄@mTiO₂ Microspheres for Highly Sensitive and Selective Enrichment of N-Glycopeptides in Amniotic Fluid.

ABSTRACT: Although mesoporous materials and magnetic materials are used to enrich glycopeptides, materials sharing both mesoporous structures and magnetic properties have not been reported for glycopeptide analyses. Here we prepared boronic acid-modified magnetic Fe₃O₄@mTiO₂ microspheres by covalent binding of boronic acid molecules onto the surfaces of silanized Fe₃O₄@mTiO₂ microspheres. The final particles (denoted as B-Fe₃O₄@mTiO₂) showed a typical magnetic hysteresis curve, indicating superparamagnetic behavior; meanwhile, their mesoporous sizes did not change in spite of the reduction in surface area and pore volume. By using these particles together with conventional poly(methyl methacrylate) (PM

SUBMITTER: Shi Z 

PROVIDER: S-EPMC5496847 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature