Screening Specific Biomarkers of Herbs Using a Metabolomics Approach: A Case Study of Panax ginseng.

ABSTRACT: Medicinal herbs belonging to the same genus are always easily confused due to their extremely similar morphology and metabolites. Previously, to differentiate them, inherently specific biomarkers were screened out via intuitive comparison of their metabolite profiles. Unfortunately, the selected biomarkers have worked only partially. Most significant specific biomarkers have been neglected. Herein, a novel method for screening specific biomarkers of medicinal herbs using a metabolomics technique was developed. Firstly, the profiles of a group of easily confused herbs belonging to the same genus were analyzed by ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry to detect all components, including low-response metabolites. Then, all components were c

SUBMITTER: Wang HP 

PROVIDER: S-EPMC5496890 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature