Ontology highlight
ABSTRACT:
SUBMITTER: Velten L
PROVIDER: S-EPMC5496982 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nature cell biology 20170320 4
Blood formation is believed to occur through stepwise progression of haematopoietic stem cells (HSCs) following a tree-like hierarchy of oligo-, bi- and unipotent progenitors. However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcriptomic and functional data at single-cell resolution to quantitatively map early differentiation of human HSCs towards lineage commitment. During homeostasis, individual HSCs gradually acquir ...[more]