Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta-analysis.

ABSTRACT:

Aims/introduction

Studies have been carried out to evaluate the correlation between TCF7L2 genetic polymorphisms and gestational diabetes mellitus (GDM) risk. However, the conclusions from these studies are incomplete, because partial single nucleotide polymorphisms (SNPs) were analyzed. We carried out a meta-analysis aimed to systematically evaluate TCF7L2 gene polymorphisms and GDM susceptibility in all population and racial/ethnic subgroups to afford a foundation for future research.

Materials and methods

Published studies censoring TCF7L2 variants and GDM risk were captured from the EMBASE, PubMed, CNKI and Wanfang databases. The meta-analysis was processed using software of RevMan 5.2 and Stata13. The relationship between TCF7L2 polymorphism and GDM occurrence was evalu

SUBMITTER: Chang S 

PROVIDER: S-EPMC5497039 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature