Circulating ferritin concentrations and risk of type 2 diabetes in Japanese individuals.

ABSTRACT:

Aims/introduction

Higher iron storage has been linked to an increased risk of type 2 diabetes, but little is known about the mediator of this association. Here, we prospectively investigated the association between circulating ferritin, a marker of iron storage, and the incidence of type 2 diabetes among Japanese individuals.

Materials and methods

The participants were 4,754 employees who attended a comprehensive health check-up in 2008-2009 and donated blood for the study. During 5 years of follow up, diabetes was identified based on plasma glucose, glycated hemoglobin and self-report. Two controls matched to each case on sex, age and date of check-up were randomly chosen using density sampling, giving 327 cases and 641 controls with ferritin measurement. Cox proportional h

SUBMITTER: Akter S 

PROVIDER: S-EPMC5497053 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature