A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway.

ABSTRACT: Traditionally, hydrogen sulfide (H₂S) was simply considered as a toxic and foul smelling gas, but recently H₂S been brought into the spot light of cardiovascular research and development. Since the 1990s, H₂S has been mounting evidence of physiological properties such as immune modification, vascular relaxation, attenuation of oxidative stress, inflammatory mitigation, and angiogenesis. H₂S has since been recognized as the third physiological gaseous signaling molecule, along with CO and NO [65,66]. H₂S is produced endogenously through several key enzymes, including cystathionine β-lyase (CBE), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST)/cysteine aminotransferase (CAT). These specific enzymes are express

SUBMITTER: Huang S 

PROVIDER: S-EPMC5497180 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature