Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease.

ABSTRACT: The 2013-2015 outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was unprecedented in the number of documented cases, but there have been few published reports on immune responses in clinical cases and their relationships with the course of illness and severity of Ebola virus disease. Symptoms of Ebola virus disease can include severe headache, myalgia, asthenia, fever, fatigue, diarrhea, vomiting, abdominal pain, and hemorrhage. Although experimental treatments are in development, there are no current U.S. Food and Drug Administration-approved vaccines or therapies. We report a detailed study of host gene expression as measured by microarray in daily peripheral blood samples collected from a patient with severe Ebola virus disease. This individual was provided with suppo

SUBMITTER: Kash JC 

PROVIDER: S-EPMC5497219 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature