Novel linkage of LMNA Single Nucleotide Polymorphism with Dilated Cardiomyopathy in an Indian case study.

ABSTRACT:

Background

Dilated Cardiomyopathy (DCM) is one of the most commonly encountered heart diseases reported globally. It is characterized by enlarged ventricles with impaired systolic and diastolic functions. Mutations in LMNA gene are one of the causative factors to precipitate the disease. However, association of SNPs of LMNA with DCM in particular has not been well documented.

Method

Here we present a limited and restricted case study of patients from south eastern part of India afflicted with idiopathic DCM and conduction defects. By using next generation sequencing we have sequenced the exons of LMNA gene from genomic DNA isolated from patients.

Result

We have identified the linkage of 8 different LMNA SNPs with idiopathic DCM viz. rs12111

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC5497236 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature