Tissue distribution and urinary excretion of intravenously administered chemically functionalized graphene oxide sheets.

ABSTRACT: The design of graphene-based materials for biomedical purposes is of great interest. Graphene oxide (GO) sheets represent the most widespread type of graphene materials in biological investigations. In this work, thin GO sheets were synthesized and further chemically functionalized with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), a stable radiometal chelating agent, by an epoxide opening reaction. We report the tissue distribution of the functionalized GO sheets labeled with radioactive indium (¹¹¹In) after intravenous administration in mice. Whole body single photon emission computed tomography (SPECT/CT) imaging, gamma counting studies, Raman microscopy and histological investigations indicated extensive urinary excretion and predominantly spleen accumulat

SUBMITTER: Jasim DA 

PROVIDER: S-EPMC5497267 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature