Comparative analysis of gut microbiota associated with body mass index in a large Korean cohort.

ABSTRACT:

Background

Gut microbiota plays an important role in the harvesting, storage, and expenditure of energy obtained from one's diet. Our cross-sectional study aimed to identify differences in gut microbiota according to body mass index (BMI) in a Korean population. 16S rRNA gene sequence data from 1463 subjects were categorized by BMI into normal, overweight, and obese groups. Fecal microbiotas were compared to determine differences in diversity and functional inference analysis related with BMI. The correlation between genus-level microbiota and BMI was tested using zero-inflated Gaussian mixture models, with or without covariate adjustment of nutrient intake.

Results

We confirmed differences between 16Sr RNA gene sequencing data of each BMI group, with decreasing diversity in

SUBMITTER: Yun Y 

PROVIDER: S-EPMC5497371 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature