Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop.

ABSTRACT: Sarcomas are a rare subgroup of pediatric cancers comprised of a variety of bone and soft-tissue tumors. While significant advances have been made in improving outcomes of patients with localized pediatric sarcomas since the addition of systemic chemotherapy to local control many decades ago, outcomes for patients with metastatic and relapsed sarcoma remain poor with few novel therapeutics identified to date. With the advent of new technologies to study cancer genomes, transcriptomes and epigenomes, our understanding of sarcoma biology has improved tremendously in a relatively short period of time. However, much remains to be accomplished in this arena especially with regard to translating all of this new knowledge to the bedside. To this end, a meeting was convened in Philadelphia, PA, on

SUBMITTER: Hingorani P 

PROVIDER: S-EPMC5497490 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature