Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.

ABSTRACT:

Background

Maternal supply of thyroid hormones during pregnancy serves a critical role in fetal development. Although animal and in vitro studies provide evidence for thyroid hormone disruption as a result of bisphenol A (BPA) exposure, there is still a lack of evidence in human studies, particularly in the context of pregnancy.

Objectives

We aimed to explore the associations between urinary BPA concentrations and plasma thyroid hormone parameters during gestation in pregnant women, and also investigated potential windows of vulnerability during gestation.

Methods

Our study population included 116 cases of preterm birth and 323 controls from a nested case-control study. We measured BPA in urine and thyroid hormone parameters in plasma samples collected at up to four s

SUBMITTER: Aung MT 

PROVIDER: S-EPMC5497503 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature