Effects of Hyperglycemia on Vascular Smooth Muscle Ca²⁺ Signaling.

ABSTRACT: Diabetes is a complex disease that is characterized with hyperglycemia, dyslipidemia, and insulin resistance. These pathologies are associated with significant cardiovascular implications that affect both the macro- and microvasculature. It is therefore important to understand the effects of various pathologies associated with diabetes on the vasculature. Here we directly test the effects of hyperglycemia on vascular smooth muscle (VSM) Ca²⁺ signaling in an isolated in vitro system using the A7r5 rat aortic cell line as a model. We find that prolonged exposure of A7r5 cells to hyperglycemia (weeks) is associated with changes to Ca²⁺ signaling, including most prominently an inhibition of the passive ER Ca²⁺ leak and the sarcoplasmic reticulum Ca²⁺

SUBMITTER: El-Najjar N 

PROVIDER: S-EPMC5497615 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature