Characterization of mitochondrial injury after cardiac arrest (COMICA).

ABSTRACT:

Introduction

Mitochondrial injury post-cardiac arrest has been described in pre-clinical settings but the extent to which this injury occurs in humans remains largely unknown. We hypothesized that increased levels of mitochondrial biomarkers would be associated with mortality and neurological morbidity in post-cardiac arrest subjects.

Methods

We performed a prospective multicenter study of post-cardiac arrest subjects. Inclusion criteria were comatose adults who suffered an out-of-hospital cardiac arrest. Mitochondrial biomarkers were measured at 0, 12, 24, 36 and 48h after return of spontaneous circulation as well as in healthy controls.

Results

Out of 111 subjects enrolled, 102 had evaluable samples at 0h. Cardiac arrest subjects had higher baseline cytochrome c lev

SUBMITTER: Donnino MW 

PROVIDER: S-EPMC5497747 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature