Satellite Repeats Identify X Chromatin for Dosage Compensation in Drosophila melanogaster Males.

ABSTRACT: A common feature of sex chromosomes is coordinated regulation of X-linked genes in one sex. Drosophila melanogaster males have one X chromosome, whereas females have two. The resulting imbalance in gene dosage is corrected by increased expression from the single X chromosome of males, a process known as dosage compensation. In flies, compensation involves recruitment of the male-specific lethal (MSL) complex to X-linked genes and modification of chromatin to increase expression. The extraordinary selectivity of the MSL complex for the X chromosome has never been explained. We previously demonstrated that the small interfering RNA (siRNA) pathway and siRNA from a family of X-linked satellite repeats (1.688^X repeats) promote X recognition. Now, we test the ability of 1.688^X</

SUBMITTER: Joshi SS 

PROVIDER: S-EPMC5497753 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature