Associations of maternal prenatal smoking with umbilical cord blood hormones: the Project Viva cohort.

ABSTRACT:

Background

Maternal smoking during pregnancy is associated with low fetal growth and adverse cardiometabolic health in offspring. However, hormonal pathways underlying these associations are unclear. Therefore, we examined maternal smoking habits and umbilical cord blood hormone profiles in a large, prospective cohort.

Methods

We studied 978 mother/infant pairs in Project Viva, a Boston-area cohort recruited 1999-2002. We categorized mothers as early pregnancy smokers, former smokers, or never smokers. Outcomes were cord blood concentrations of IGF-1, IGF-2, IGFBP-3, leptin, adiponectin, insulin, and C-peptide. We used linear regression models adjusted for maternal pre-pregnancy body mass index (BMI), race/ethnicity, parity, education, and infant sex. We conducted analyses i

SUBMITTER: Fleisch AF 

PROVIDER: S-EPMC5497769 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature