A distinct innate lymphoid cell population regulates tumor-associated T cells.

ABSTRACT: Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56⁺CD3^- population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production. Transcriptome analysis and phenotypic characterization determined that regul

SUBMITTER: Crome SQ 

PROVIDER: S-EPMC5497996 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature