Sirolimus Increases T-Cell Abundance in the Sun Exposed Skin of Kidney Transplant Recipients.

ABSTRACT:

Background

Kidney transplant recipients (KTRs) receiving the mammalian target of rapamycin inhibitor sirolimus may display a reduced risk of skin cancer development compared to KTRs receiving calcineurin inhibitors. Despite studies investigating the effects of these 2 drug classes on T cells in patient blood, the effect these drugs may have in patient skin is not yet known.

Methods

Fifteen patients with chronic kidney disease (not recipients of immunosuppressive drugs), and 30 KTRs (15 receiving a calcineurin inhibitor, and 15 receiving sirolimus) provided matched samples of blood, sun exposed (SE) and non-SE skin. The abundance of total CD8⁺ and CD4⁺ T cells, memory CD8⁺ and CD4⁺ T cells, and regulatory T (Treg) cells in each samp

SUBMITTER: Burke MT 

PROVIDER: S-EPMC5498012 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature