Gut bacterial peptides with autoimmunity potential as environmental trigger for late onset complex diseases: In-silico study.

ABSTRACT: Recent evidences suggest that human gut microbiota with major component as bacteria can induce immunity. It is also known that gut lining depletes with ageing and that there is increased risk of autoimmune and inflammatory disorders with ageing. It is therefore likely that both may be correlated as depletion of gut lining exposes the gut bacterial antigens to host immune mechanisms, which may induce immunity to certain bacterial proteins, but at the same time such immunity may also be auto-immunogenic to host. This autoimmunity may make a protein molecule nonfunctional and thereby may be involved in late onset metabolic, autoimmune and inflammatory disorders such as, Diabetes, Rheumatoid Arthritis, Hyperlipidemias and Cancer. In this in-silico study we found a large number of peptides iden

SUBMITTER: Negi S 

PROVIDER: S-EPMC5498033 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature