The effect of infectious dose on humoral and cellular immune responses in Chlamydophila caviae primary ocular infection.

ABSTRACT: Following infection, the balance between protective immunity and immunopathology often depends on the initial infectious load. Several studies have investigated the effect of infectious dose; however, the mechanism by which infectious dose affects disease outcomes and the development of a protective immune response is not known. The aim of this study was to investigate how the infectious dose modulates the local and systemic humoral and the cellular immune responses during primary ocular chlamydial infection in the guinea pig animal model. Guinea pigs were infected by ocular instillation of a Chlamydophila caviae-containing eye solution in the conjunctival sac in three different doses: 1×102, 1×104, and 1×106 inclusion forming units (IFUs). Ocular pathology, chlamydial clearance, local and

SUBMITTER: Filipovic A 

PROVIDER: S-EPMC5498042 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature