Self-regulatory factors of embryonic stem cells in co-culture with stromal cells enhance neural differentiation.

ABSTRACT: Embryonic stem cells (ESCs), due to their intrinsic capability to generate somatic cells of all three germ layers, are potential sources of neural cells for cell replacement therapies. However, the empirical differentiation protocols and the lack of mechanistic understanding of the neural differentiation of ESCs have limited the utility of ESCs as a developmental model or as a cell source for neural cell populations for replacement therapies. Co-culturing ESCs with stromal cells is one of the extensively used methods to induce neural differentiation. Despite several studies to identify neural inducing factors in stromal cell induced neural differentiation, the self-regulatory effects of ESCs in the neural differentiation process remain unexplored. For the first time, we elucidate the self-

SUBMITTER: Joshi R 

PROVIDER: S-EPMC5498101 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature