A Multiplexed, Heterogeneous, and Adaptive Code for Navigation in Medial Entorhinal Cortex.

ABSTRACT: Medial entorhinal grid cells display strikingly symmetric spatial firing patterns. The clarity of these patterns motivated the use of specific activity pattern shapes to classify entorhinal cell types. While this approach successfully revealed cells that encode boundaries, head direction, and running speed, it left a majority of cells unclassified, and its pre-defined nature may have missed unconventional, yet important coding properties. Here, we apply an unbiased statistical approach to search for cells that encode navigationally relevant variables. This approach successfully classifies the majority of entorhinal cells and reveals unsuspected entorhinal coding principles. First, we find a high degree of mixed selectivity and heterogeneity in superficial entorhinal neurons. Second, we dis

SUBMITTER: Hardcastle K 

PROVIDER: S-EPMC5498174 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature