Functional dynamics of hippocampal glutamate during associative learning assessed with in vivo ¹H functional magnetic resonance spectroscopy.

ABSTRACT: fMRI has provided vibrant characterization of regional and network responses associated with associative learning and memory; however, their relationship to functional neurochemistry is unclear. Here, we introduce a novel application of in vivo proton functional magnetic resonance spectroscopy (¹H fMRS) to investigate the dynamics of hippocampal glutamate during paired-associated learning and memory in healthy young adults. We show that the temporal dynamics of glutamate differed significantly during processes of memory consolidation and retrieval. Moreover, learning proficiency was predictive of the temporal dynamics of glutamate such that fast learners were characterized by a significant increase in glutamate levels early in learning, whereas this increase was only observed la

SUBMITTER: Stanley JA 

PROVIDER: S-EPMC5498221 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature