Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area.

ABSTRACT:

Background

To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations.

Methods

The authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first-degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC.

Results

Individuals with a first-degree family history of NPC were found

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5498222 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature