Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography.

ABSTRACT:

Introduction

Dystrophic muscle is particularly susceptible to eccentric contraction-induced injury. We tested the hypothesis that electrical impedance myography (EIM) can detect injury induced by maximal-force lengthening contractions.

Methods

We induced injury in the quadriceps of wild-type (WT) and dystrophic (mdx) mice with eccentric contractions using an established model.

Results

mdx quadriceps had significantly greater losses in peak twitch and tetany compared with losses in WT quadriceps. Injured muscle showed a significant increase in EIM characteristic frequency in both WT (177 ± 7.7%) and mdx (167 ± 7.8%) quadriceps. EIM also revealed decreased extracellular resistance for both WT and mdx quadriceps after injury.

Discussion

Our results show overall ag

SUBMITTER: Sanchez B 

PROVIDER: S-EPMC5498260 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature