Association of HIV infection with biomarkers of kidney injury and fibrosis in the Multicenter AIDS Cohort Study.

ABSTRACT:

Background

Chronic kidney disease (CKD) is common among HIV-infected individuals but serum creatinine is insensitive for detecting kidney damage at early stages. We hypothesized that HIV infection would be associated with elevations in subclinical markers of kidney injury and fibrosis in a contemporary cohort of men.

Methods

In this cross-sectional study, we measured urine levels of interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), pro-collagen type III N-terminal pro-peptide (PIIINP) and albumin-creatinine ratio (ACR) in 813 HIV-infected and 331 uninfected men enrolled in the Multicenter AIDS Cohort Study.

Results

Median eGFR was 95 ml/min/1.73 m² among African-Americans (n=376) and 87 ml/min/1.73 m² among Caucasians (n=768). Among HIV-i

SUBMITTER: Jotwani V 

PROVIDER: S-EPMC5498264 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature