Opioid use during pregnancy: a population-based cohort study.

ABSTRACT:

Background

Opioid use has increased dramatically in North America. The safety of opioids in pregnancy is uncertain, but they are associated with several fetal abnormalities and contribute to rising rates of neonatal abstinence syndrome. We examined opioid use before and during pregnancy in a complete population-based cohort.

Methods

We examined opioid use in a cohort of all pregnant women in Manitoba, Canada, from 2001 to 2013. Opioid use was defined by prescriptions for opioids, converted to oral morphine equivalents (MEQ), during the 3 months before pregnancy and for each trimester. Given that the exposure per person may vary (because not all women complete all time periods), we determined a weighted number of pregnancies in each period.

Results

During the study per

SUBMITTER: Falk J 

PROVIDER: S-EPMC5498419 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature