A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand.

ABSTRACT: Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30-40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic populations and the geographical location of the populations. To address this issue, a total of 688 samples from 13 different northern Thai ethnic groups (30 villages) categorized into three linguistic groups were genotyped for deletional alpha-thalassaemia (-α^3.7, -α^4.2, --^SEA and --^THAI) and/or non-deletional alpha-thalassaemia (α^CS and α^PS) via multiplex gap-PCR and dot-blot hybridization, respectively. Alpha⁺(-α^3.7

SUBMITTER: Kulaphisit M 

PROVIDER: S-EPMC5498591 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature