A Novel Unsupervised Algorithm for Biological Process-based Analysis on Cancer.

ABSTRACT: The aberrant alterations of biological functions are well known in tumorigenesis and cancer development. Hence, with advances in high-throughput sequencing technologies, capturing and quantifying the functional alterations in cancers based on expression profiles to explore cancer malignant process is highlighted as one of the important topics among cancer researches. In this article, we propose an algorithm for quantifying biological processes by using gene expression profiles over a sample population, which involves the idea of constructing principal curves to condense information of each biological process by a novel scoring scheme on an individualized manner. After applying our method on several large-scale breast cancer datasets in survival analysis, a subset of these biological proces

SUBMITTER: Song T 

PROVIDER: S-EPMC5498659 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature