Ontology highlight
ABSTRACT:
SUBMITTER: Nixon CE
PROVIDER: S-EPMC5498721 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Clinical and vaccine immunology : CVI 20170705 7
Naturally acquired antibodies to <i>Plasmodium falciparum</i> schizont egress antigen 1 (PfSEA-1A) are associated with protection against severe malaria in children. Vaccination of mice with SEA-1A from <i>Plasmodium berghei</i> (PbSEA-1A) decreases parasitemia and prolongs survival following <i>P. berghei</i> ANKA challenge. To enhance the immunogenicity of PfSEA-1A, we identified five linear B-cell epitopes using peptide microarrays probed with antisera from nonhuman primates vaccinated with r ...[more]