Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma.

ABSTRACT: The effective treatment of glioma is largely hindered by the poor transfer of drug delivery systems across the blood-brain barrier (BBB) and the difficulty in distinguishing healthy and tumorous cells. In this work, for the first time, an interleukin-6 receptor binding I₆P₇ peptide was exploited as a cascade-targeting ligand in combination with a succinoyl tetraethylene pentamine (Stp)-histidine oligomer-based nonviral gene delivery system (I₆P₇-Stp-His/DNA). The I₆P₇ peptide provides multiple functions, including the cascade-targeting potential represented by a combined BBB-crossing and subsequent glioma-targeting ability, as well as a direct tumor-inhibiting effect. I₆P₇-Stp-His/DNA nanoparticles (NPs

SUBMITTER: Wang S 

PROVIDER: S-EPMC5498832 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature