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Fish Scale Collagen Peptides Protect against CoCl₂/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.

ABSTRACT: Skin diseases associated with inflammation or oxidative stress represent the most common problem in dermatology. The present study demonstrates that fish scale collagen peptides (FSCP) protect against CoCl₂-induced cytotoxicity and TNF-α-induced inflammatory responses in human HaCaT keratinocyte cells. Our study is the first to report that FSCP increase cell viability and ameliorate oxidative injury in HaCaT cells through mechanisms mediated by the downregulation of key proinflammatory cytokines, namely, TNF-α, IL-1β, IL-8, and iNOS. FSCP also prevent cell apoptosis by repressing Bax expression, caspase-3 activity, and cytochrome c release and by upregulating Bcl-2 protein levels in CoCl₂- or TNF-α-stimulated HaCaT cells. In addition, the i

SUBMITTER: Subhan F

PROVIDER: S-EPMC5498912 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dataset Information

Fish Scale Collagen Peptides Protect against CoCl₂/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Fish Scale Collagen Peptides Protect against CoCl2/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Fish Scale Collagen Peptides Protect against CoCl₂/TNF-α-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-κB Pathways in HaCaT Cells.