Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.

ABSTRACT:

Background

Some gout-associated loci interact with dietary exposures to influence outcome. The aim of this study was to systematically investigate interactions between alcohol exposure and urate-associated loci in gout.

Methods

A total of 2792 New Zealand European and Polynesian (Māori or Pacific) people with or without gout were genotyped for 29 urate-associated genetic variants and tested for a departure from multiplicative interaction with alcohol exposure in the risk of gout. Publicly available data from 6892 European subjects were used to test for a departure from multiplicative interaction between specific loci and alcohol exposure for the risk of hyperuricemia (HU). Multivariate adjusted logistic and linear regression was done, including an interaction term.

Result

SUBMITTER: Rasheed H 

PROVIDER: S-EPMC5499049 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature