A Pathway-Centered Analysis of Pig Domestication and Breeding in Eurasia.

ABSTRACT: Ascertaining the molecular and physiological basis of domestication and breeding is an active area of research. Due to the current wide distribution of its wild ancestor, the wild boar, the pig (Sus scrofa) is an excellent model to study these processes, which occurred independently in East Asia and Europe ca. 9000 yr ago. Analyzing genome variability patterns in terms of metabolic pathways is attractive since it considers the impact of interrelated functions of genes, in contrast to genome-wide scans that treat genes or genome windows in isolation. To that end, we studied 40 wild boars and 123 domestic pig genomes from Asia and Europe when metabolic pathway was the unit of analysis. We computed statistical significance for differentiation (Fst) and linkage disequilibrium (nSL) stat

SUBMITTER: Leno-Colorado J 

PROVIDER: S-EPMC5499126 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature