The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena.

ABSTRACT: The mechanisms that govern pattern formation within the cell are poorly understood. Ciliates carry on their surface an elaborate pattern of cortical organelles that are arranged along the anteroposterior and circumferential axes by largely unknown mechanisms. Ciliates divide by tandem duplication: the cortex of the predivision cell is remodeled into two similarly sized and complete daughters. In the conditional cdaI-1 mutant of Tetrahymena thermophila, the division plane migrates from its initially correct equatorial position toward the cell's anterior, resulting in unequal cell division, and defects in nuclear divisions and cytokinesis. We used comparative whole genome sequencing to identify the cause of cdaI-1 as a mutation in a Hippo/Mst kinase. CdaI is a cortical p

SUBMITTER: Jiang YY 

PROVIDER: S-EPMC5499192 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature