Putative enhancer sites in the bovine genome are enriched with variants affecting complex traits.

ABSTRACT:

Background

Enhancers are non-coding DNA sequences, which when they are bound by specific proteins increase the level of gene transcription. Enhancers activate unique gene expression patterns within cells of different types or under different conditions. Enhancers are key contributors to gene regulation, and causative variants that affect quantitative traits in humans and mice have been located in enhancer regions. However, in the bovine genome, enhancers as well as other regulatory elements are not yet well defined. In this paper, we sought to improve the annotation of bovine enhancer regions by using publicly available mammalian enhancer information. To test if the identified putative bovine enhancer regions are enriched with functional variants that affect milk production traits,

SUBMITTER: Wang M 

PROVIDER: S-EPMC5499214 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature