Evolution of Osteocrin as an activity-regulated factor in the primate brain.
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ABSTRACT:
SUBMITTER: Ataman B
PROVIDER: S-EPMC5499253 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Ataman Bulent B Boulting Gabriella L GL Harmin David A DA Yang Marty G MG Baker-Salisbury Mollie M Yap Ee-Lynn EL Malik Athar N AN Mei Kevin K Rubin Alex A AA Spiegel Ivo I Durresi Ershela E Sharma Nikhil N Hu Linda S LS Pletikos Mihovil M Griffith Eric C EC Partlow Jennifer N JN Stevens Christine R CR Adli Mazhar M Chahrour Maria M Sestan Nenad N Walsh Christopher A CA Berezovskii Vladimir K VK Livingstone Margaret S MS Greenberg Michael E ME
Nature 20161101 7628
Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it is not known whether there are species- or clade-specific activity-regulated genes that control features of brain development and function. Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted ...[more]
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