Ontology highlight
ABSTRACT:
SUBMITTER: Battula VL
PROVIDER: S-EPMC5499365 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
JCI insight 20170706 13
Genotypic and phenotypic alterations in the bone marrow (BM) microenvironment, in particular in osteoprogenitor cells, have been shown to support leukemogenesis. However, it is unclear how leukemia cells alter the BM microenvironment to create a hospitable niche. Here, we report that acute myeloid leukemia (AML) cells, but not normal CD34+ or CD33+ cells, induce osteogenic differentiation in mesenchymal stromal cells (MSCs). In addition, AML cells inhibited adipogenic differentiation of MSCs. Me ...[more]