Statin Use and the Risk of Type 2 Diabetes Mellitus in Children and Adolescents.

ABSTRACT:

Objective

There is increasing evidence of an association between statin use and type 2 diabetes mellitus (T2DM) in adults, yet this relationship has never been studied in children or adolescents and may have important implications for assessing risks and benefits of treatment in this population. We estimated the association between statin use and the risk of T2DM in children with and without a dyslipidemia diagnosis.

Methods

Propensity scores were used to match new users of statins with a minimum 50 percent of days covered (PDC) in the first year of use to up to 10 nonusers. Analyses were stratified by a dyslipidemia diagnosis based on recent evidence suggesting a potentially protective effect of familial hypercholesterolemia on T2DM. In sensitivity analyses, we varied this

SUBMITTER: Joyce NR 

PROVIDER: S-EPMC5499509 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature