The DAU cluster: a comparative analysis of 18 RHD alleles, some forming partial D antigens.

ABSTRACT:

Background

The Rh system is the most complex and polymorphic blood group system in humans with more than 460 alleles known for the RHD gene. The DAU cluster of RHD alleles is characterized by the single-nucleotide change producing the p.Thr379Met amino acid substitution. It is called the DAU-0 allele and has been postulated to be the primordial allele, from which all other alleles of the DAU cluster have eventually evolved.

Study design and methods

For two novel DAU alleles, the nucleotide sequences of all 10 exons as well as adjacent intronic regions, including the 5' and 3' untranslated regions (UTR), were determined for the RHD and RHCE genes. A phylogenetic tree for all DAU alleles was established using the neighbor-joining method with Pan troglodytes as root. Standard h

SUBMITTER: Srivastava K 

PROVIDER: S-EPMC5499517 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature