Blood transcriptomic comparison of individuals with and without autism spectrum disorder: A combined-samples mega-analysis.

ABSTRACT: Blood-based microarray studies comparing individuals affected with autism spectrum disorder (ASD) and typically developing individuals help characterize differences in circulating immune cell functions and offer potential biomarker signal. We sought to combine the subject-level data from previously published studies by mega-analysis to increase the statistical power. We identified studies that compared ex vivo blood or lymphocytes from ASD-affected individuals and unrelated comparison subjects using Affymetrix or Illumina array platforms. Raw microarray data and clinical meta-data were obtained from seven studies, totaling 626 affected and 447 comparison subjects. Microarray data were processed using uniform methods. Covariate-controlled mixed-effect linear models were used to identify gen

SUBMITTER: Tylee DS 

PROVIDER: S-EPMC5499528 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature